| Week 4 | Alberto | Eric | Greg | JoAnn | Joe | Karl | Kathy | Neal | Olga | Sandy | ||||
| Sunday, October 4 | ||||||||||||||
| Away | Home | Stadium | Time | Network | ||||||||||
| Tampa Bay (0-3, Road: 0-1) | Washington (1-2, Home: 1-0) | FedEx Field | 1:00 PM | FOX | Washington | Washington | Washington | Washington | Washington | Washington | Washington | Washington | Washington | Tampa Bay |
| Baltimore (3-0, Road: 1-0) | New England (2-1, Home: 2-0) | Gillette Stadium | 1:00 PM | CBS | Baltimore | Baltimore | Baltimore | Baltimore | New England | Baltimore | New England | Baltimore | New England | New England |
| Detroit (1-2, Road: 0-1) | Chicago (2-1, Home: 1-0) | Soldier Field | 1:00 PM | FOX | Chicago | Chicago | Chicago | Chicago | Chicago | Chicago | Chicago | Chicago | Chicago | Chicago |
| Tennesee (0-3, Road: 0-2) | Jacksonville (1-2, Home: 0-1) | Jacksonville Municipal Stadium | 1:00 PM | CBS | Tennesee | Jacksonville | Tennesee | Jacksonville | Tennesee | Tennesee | Tennesee | Tennesee | Tennesee | Jacksonville |
| Oakland (1-2, Road: 1-0) | Houston (1-2, Home: 0-2) | Reliant Stadium | 1:00 PM | CBS | Houston | Houston | Houston | Oakland | Oakland | Houston | Houston | Oakland | Houston | Oakland |
| Cincinatti (2-1, Road: 1-0) | Cleveland (0-3, Home: 0-1) | Cleveland Browns Stadium | 1:00 PM | CBS | Cincinatti | Cincinatti | Cincinatti | Cincinatti | Cincinatti | Cincinatti | Cincinatti | Cincinatti | Cincinatti | Cleveland |
| Seattle (1-2, Road: 0-1) | Inianapolis (3-0, Home: 1-0) | Lucas Oil Stadium | 1:00 PM | FOX | Indianapolis | Indianapolis | Indianapolis | Indianapolis | Indianapolis | Indianapolis | Indianapolis | Indianapolis | Indianapolis | Indianapolis |
| New York Giants (3-0, Road: 2-0) | Kansas City (0-3, Home: 0-1) | Arrowhead Stadium | 1:00 PM | FOX | New York Giants | New York Giants | New York Giants | New York Giants | New York Giants | New York Giants | New York Giants | New York Giants | New York Giants | New York Giants |
| Buffalo (1-2, Road: 0-1) | Miami (0-3, Home: 0-1) | Land Shark Stadium | 4:05 PM | CBS | Buffalo | Buffalo | Buffalo | Buffalo | Buffalo | Buffalo | Miami | Buffalo | Buffalo | Buffalo |
| New York Jets (3-0, Road: 1-0) | New Orleans (3-0, Home: 1-0) | Superdome | 4:05 PM | CBS | New Orleans | New Orleans | New Orleans | New Orleans | New York Jets | New York Jets | New Orleans | New York Jets | New Orleans | New York Jets |
| St. Louis (0-3, Road: 0-2) | San Francisco (2-1, Home: 1-0) | Candlestick Park | 4:15 PM | FOX | San Fancisco | San Fancisco | San Fancisco | San Fancisco | San Fancisco | San Fancisco | San Fancisco | San Fancisco | San Fancisco | St. Louis |
| Dallas (2-1, Road: 1-0) | Denver (3-0, Home: 1-0) | Invesco Field at Mile High | 4:15 PM | FOX | Dallas | Denver | Dallas | Denver | Dallas | Denver | Denver | Denver | Dallas | Dallas |
| San Diego (2-1, Road: 1-0) | Pittsburgh (1-2, Home: 1-0) | Heinz Field | 8:20 PM | NBC | Pittsburgh | San Diego | Pittsburgh | Pittsburgh | San Diego | Pittsburgh | Pittsburgh | Pittsburgh | Pittsburgh | San Diego |
| Monday, October 5 | ||||||||||||||
| Away | Home | Stadium | Time | Network | ||||||||||
| Green Bay (2-1, Road: 1-0) | Minnesota (3-0, Home: 1-0) | Hubert H. Humphrey Metrodome | 8:30 PM | ESPN | Minnesota | Green Bay | Minnesota | Green Bay | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Green Bay |
| TIE | ||||||||||||||
| WIN | ||||||||||||||
| Alberto | Eric | Greg | JoAnn | Joe | Karl | Kathy | Neal | Olga | Sandy | |||||
| 10 | 10 | 10 | 10 | 8 | 10 | 13 | 9 | 11 | 5 |