| Week 12 | Alberto | Eric | Greg | JoAnn | Joe | Karl | Kathy | Neal/Joc | Olga | Sandy | ||||
| Thursday, November 26 | ||||||||||||||
| Away | Home | Stadium | Time | Network | ||||||||||
| Green Bay 6-4 (Road: 2-2) | Detroit 2-8 (Home: 2-3) | Ford Field | 12:30 PM | FOX | Green Bay | Green Bay | Green Bay | Green Bay | Green Bay | Green Bay | Green Bay | Green Bay | Green Bay | Green Bay |
| Oakland 3-7 (Road: 1-3) | Dallas 7-3 (Home: 4-1) | Cowboys Stadium | 4:15 PM | CBS | Oakland | Dallas | Dallas | Dallas | Dallas | Dallas | Dallas | Dallas | Dallas | Dallas |
| New York Giants 6-4 (Road: 3-2) | Denver 6-4 (Home: 3-2) | Invesco Field at Mile High | 8:20 PM | NFLN | New York Giants | New York Giants | Denver | New York Giants | New York Giants | New York Giants | New York Giants | Denver | New York Giants | New York Giants |
| Sunday, November 29 | ||||||||||||||
| Away | Home | |||||||||||||
| Tampa Bay 1-9 (Road: 0-4) | Atlanta 5-5 (Home: 4-0) | Bank of America Stadium | 1:00 PM | FOX | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Tampa Bay |
| Miami 5-5 (Road: 2-3) | Buffalo 3-7 (Home: 1-3) | Giants Stadium | 1:00 PM | CBS | Buffalo | Miami | Miami | Miami | Miami | Miami | Miami | Miami | Miami | Buffalo |
| Carolina 4-6 (Road: 2-3) | New York Jets 4-6 (Home: 2-3) | Mall of America Field | 1:00 PM | FOX | Carolina | Carolina | New York Jets | New York Jets | Carolina | New York Jets | Carolina | New York Jets | Carolina | Carolina |
| Seattle 4-6 (Home: 2-3) | St. Louis 1-9 (Home: 0-5) | Land Shark Stadium | 1:00 PM | FOX | Seattle | Seattle | Seattle | Seattle | Seattle | Seattle | Seattle | St. Louis | Seattle | Seattle |
| Washington 3-7 (Road: 0-5) | Philadelphia 6-4 (Home: 3-2) | Heinz Field | 1:00 PM | FOX | Philadelphia | Philadelphia | Philadelphia | Washington | Philadelphia | Washington | Philadelphia | Philadelphia | Philadelphia | Philadelphia |
| Cleveland 1-9 (Road: 1-5) | Cincinnati 7-3 (Home: 3-2) | LP Field | 1:00 PM | CBS | Cincinnati | Cincinnati | Cincinnati | Cincinnati | Cincinnati | Cincinnati | Cincinnati | Cincinnati | Cincinnati | Cincinnati |
| Inianapolis 10-0 (Road: 5-0) | Houston 5-5 (Home: 2-3) | FedEx Field | 1:00 PM | CBS | Indianapolis | Indianapolis | Indianapolis | Indianapolis | Inianapolis | Inianapolis | Inianapolis | Inianapolis | Inianapolis | Inianapolis |
| Kansas City 3-7 (Road: 2-3) | San Diego 7-3 (Home: 3-2) | Edward Jones Dome | 4:05 PM | CBS | San Diego | San Diego | San Diego | San Diego | San Diego | San Diego | San Diego | San Diego | San Diego | San Diego |
| Jacksonville 6-4 (Road: 2-3) | San Francisco 4-6 (Home: 3-2) | Oakland Coliseum | 4:05 PM | CBS | San Francisco | Jacksonville | San Francisco | Jacksonville | Jacksonville | Jacksonville | San Francisco | Jacksonville | Jacksonville | San Francisco |
| Chicago 4-6 (Road: 1-4) | Minnesota 9-1 (Home: 5-0) | University of Phoenix Stadium | 4:15 PM | FOX | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota |
| Arizona 7-3 (Road: 5-0) | Tennesee 4-6 (Home: 2-2) | Lambeau Field | 4:15 PM | FOX | Arizona | Tennesee | Arizona | Arizona | Arizona | Tennesee | Tennesee | Tennesee | Arizona | Tennesee |
| Pittsburgh 6-4 (Road: 2-3) | Baltimore 5-5 (Home: 3-2) | University of Phoenix Stadium | 8:20 PM | NBC | Baltimore | Pittsburgh | Baltimore | Baltimore | Baltimore | Pittsburgh | Pittsburgh | Baltimore | Pittsburgh | Pittsburgh |
| Monday, November 30 | ||||||||||||||
| Away | Home | Stadium | Time | Network | ||||||||||
| New England 7-3 (Road: 1-3) | New Orleans 10-0 (Home: 5-0) | Cleveland Browns Stadium | 8:30 PM | ESPN | New England | New Orleans | New Orleans | New Orleans | New Orleans | New England | New England | New Orleans | New England | New England |
| Alberto | Eric | Greg | JoAnn | Joe | Karl | Kathy | Neal/Joc | Olga | Sandy | |||||
| 11 | 10 | 13 | 10 | 10 | 10 | 11 | 12 | 9 | 11 |