| Week 10 | Alberto | Eric | Greg | JoAnn | Joe | Karl | Kathy | Neal | Olga | Sandy | ||||
| Thursday, November 12 | ||||||||||||||
| Away | Home | Stadium | Time | Network | ||||||||||
| Chicago (4-4, Road: 1-3) | San Francisco (3-5, Home: 2-2) | Candlestick Park | 8:20 PM | NFLN | Chicago | San Francisco | San Francisco | Chicago | San Francisco | San Francisco | San Francisco | San Francisco | Chicago | Chicago |
| Sunday, November 15 | ||||||||||||||
| Away | Home | |||||||||||||
| Atlanta (5-3, Road: 1-3) | Carolina (3-5, Home: 1-2) | Bank of America Stadium | 1:00 PM | FOX | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta | Atlanta |
| Jacksonville (4-4, Road: 1-3) | New York Jets (4-4, Home: 2-2) | Giants Stadium | 1:00 PM | CBS | New York Jets | Jacksonville | New York Jets | New York Jets | New York Jets | New York Jets | Jacksonville | New York Jets | New York Jets | New York Jets |
| Detroit (1-7, Road: 0-4) | Minnesota (7-1, Home: 3-0) | Mall of America Field | 1:00 PM | FOX | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota | Minnesota |
| Tampa Bay (1-7, Road: 0-3) | Miami 2-4 (3-5, Home: 2-2) | Land Shark Stadium | 1:00 PM | FOX | Miami | Miami | Miami | Miami | Miami | Miami | Miami | Miami | Miami | Miami |
| Cincinnatti (6-2, Road: 3-0) | Pittsburgh (6-2, Home: 4-0) | Heinz Field | 1:00 PM | CBS | Pittsburgh | Cincinnatti | Pittsburgh | Pittsburgh | Pittsburgh | Pittsburgh | Pittsburgh | Pittsburgh | Pittsburgh | Pittsburgh |
| Buffalo (3-5, Road: 2-2) | Tennesee (2-6, Home: 1-2) | LP Field | 1:00 PM | CBS | Buffalo | Tennessee | Tennessee | Tennessee | Tennessee | Tennessee | Tennessee | Buffalo | Tennessee | Tennessee |
| Denver (6-2, Road: 3-1) | Washington (2-6, Home: 2-2) | FedEx Field | 1:00 PM | CBS | Denver | Denver | Denver | Denver | Denver | Denver | Denver | Denver | Denver | Denver |
| New Orleans (8-0, Road: 3-0) | St. Louis (1-7, Home: 0-3) | Edward Jones Dome | 1:00 PM | FOX | New Orleans | New Orleans | New Orleans | New Orleans | New Orleans | New Orleans | New Orleans | New Orleans | New Orleans | New Orleans |
| Kansas City (1-7, Road: 1-3) | Oakland (2-6, Home: 1-3) | Oakland Coliseum | 4:05 PM | CBS | Kansas City | Kansas City | Oakland | Kansas City | Oakland | Kansas City | Kansas City | Oakland | Oakland | Kansas City |
| Seattle (3-5, Road: 0-3) | Arizona (5-3, Home: 1-3) | University of Phoenix Stadium | 4:15 PM | FOX | Arizona | Arizona | Arizona | Arizona | Arizona | Arizona | Arizona | Arizona | Arizona | Arizona |
| Dallas (6-2, Road: 3-1) | Green Bay (4-4, Home: 2-2) | Lambeau Field | 4:15 PM | FOX | Dallas | Green Bay | Dallas | Green Bay | Dallas | Dallas | Dallas | Dallas | Dallas | Dallas |
| Philadelphia (5-3, Road: 2-1) | San Diego (5-3, Home: 2-2) | Qualcomm Stadium | 4:15 PM | FOX | Philadelphia | Philadelphia | Philadelphia | San Diego | San Diego | San Diego | San Diego | Philadelphia | Philadelphia | Philadelphia |
| New England (6-2, Road: 1-2) | Indianapolis (8-0, Home: 4-0) | Lucas Oil Stadium | 8:20 PM | NBC | Indianapolis | Indianapolis | Indianapolis | Indianapolis | New England | Indianapolis | Indianapolis | Indianapolis | New England | New England |
| Away | Home | Stadium | Time | Network | ||||||||||
| Baltimore (4-4, Road: 1-3) | Cleveland (1-7, Home: 0-3) | Cleveland Browns Stadium | 8:30 PM | ESPN | Baltimore | Baltimore | Baltimore | Baltimore | Baltimore | Baltimore | Baltimore | Baltimore | Baltimore | Baltimore |
| Byes: Texans, Giants | ||||||||||||||
| Due 11/12 @ noon | ||||||||||||||
| Alberto | Eric | Greg | JoAnn | Joe | Karl | Kathy | Neal | Olga | Sandy | |||||
| 6 | 11 | 7 | 9 | 7 | 9 | 10 | 6 | 5 | 6 |